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Updated: Jul 11, 2026

A Simple and Efficient Method to Detect Nuclear Factor Activation in Human Neutrophils by Flow Cytometry
Published on: April 9, 2013
Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha
Xiuping Liu1, Changyun Xiong, Chunhong Li
1College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China. Liuxiuping2006@gmail.com
Abstract:
Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
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