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Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling

Gong Chen1, Qian Wan, Zhongping Tan

  • 1Laboratory of Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 106, New York, NY 10021, USA.

Angewandte Chemie (International Ed. in English)
|September 11, 2007
PubMed
Abstract

No abstract available in PubMed .

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Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...