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Updated: Jul 11, 2026
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Epstein Barr virus induced lymphoma in a child with IPEX syndrome
Kenneth G Lucas1, David Ungar, Melanie Comito
1Division of Hematology/Oncology, Stem Cell Transplantation Program, Department of Pediatrics, Penn State Children's Hospital, 500 University Drive, C7830, MC H085, Hershey, Pennsylvania 17033, USA. klucas@psu.edu
Abstract:
IPEX syndrome (immune deficiency, polyendocrinopathy, enteropathy, X-linked) is a disorder or regulatory T cell (Treg) function which can result in early death due to infection or complications related to autoimmunity. Therapeutic options for these patients can include allogeneic stem cell transplantation (SCT) or the use of immunosuppressive regimens to control the manifestations of autoimmunity. We report a patient with IPEX syndrome who was managed with rapamycin and subsequently developed EBV induced lymphoma.
