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Related Experiment Videos

Chromatography with supercritical fluids.

M L Lee, K E Markides

    Science (New York, N.Y.)
    |March 13, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Supercritical fluid chromatography (SFC) uses unique supercritical fluids as a mobile phase, offering advanced analysis for reactive and sensitive compounds. This review covers SFC history, instrumentation, and unique elution control methods.

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    Area of Science:

    • Analytical Chemistry
    • Separation Science

    Background:

    • Supercritical fluid chromatography (SFC) utilizes supercritical fluids as a mobile phase, bridging gas and liquid chromatography.
    • SFC is gaining prominence for analyzing reactive, thermally labile, and nonvolatile compounds due to unique fluid properties.

    Purpose of the Study:

    • To provide a comprehensive review of supercritical fluid chromatography (SFC).
    • To highlight the history, instrumentation, and practical applications of SFC.
    • To emphasize unique elution control methods in SFC.

    Main Methods:

    • Review of historical development and instrumentation in SFC.
    • Discussion of practical aspects and applications of SFC.
    • Detailed examination of various programming methods for selective elution control in SFC.

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    Main Results:

    • SFC enables the analysis of challenging compounds previously difficult to separate.
    • Unique properties of supercritical fluids offer distinct separation advantages.
    • Programming methods provide novel ways to control analyte elution in SFC.

    Conclusions:

    • SFC is a powerful and versatile separation technique for complex analyses.
    • Understanding SFC instrumentation and programming is key to its effective application.
    • SFC offers unique advantages for analyzing reactive, labile, and nonvolatile substances.