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Linkage of plasminogen (PLG) and apolipoprotein(a) (LPA) in baboons
J L VandeBerg1, L Weitkamp, C M Kammerer
1Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
Genomics
|December 1, 1991
Abstract:
Four allelic forms of serum plasminogen (PLG) were detected in baboons (Papio hamadryas Linneaus 1758) by isoelectric focusing and were determined to be inherited as autosomal codominant traits. Linkage analysis of data from 179 progeny and their parents revealed that PLG is tightly linked (lod score = 30.20) to the gene encoding apolipoprotein(a) (LPA), as in humans. No recombinant individuals were identified. This is the first linkage detected between PLG and LPA in any species other than humans and is the first genetic linkage identified in a nonhuman primate species by family studies.