Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Echinococcus multilocularis antigens modify accessory cell function of macrophages.

N K Rakha1, J B Dixon, S D Carter

  • 1Department of Veterinary Pathology, Faculty of Veterinary Science, School of Tropical Medicine, University of Liverpool.

Immunology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interventional Oncology Geographic Inequality-A Problem for Today.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Findings from interviews with pilots on spatial disorientation: training, temporal dynamics and countermeasures.

Frontiers in physiology·2026
Same author

IO1-UK: a cross-sectional study to re-evaluate the provision of interventional oncology services across the United Kingdom.

Clinical radiology·2026
Same author

Time to Splenic Embolisation in Trauma Patients Arriving at a Major Trauma Centre In-Hours or Out-of-Hours: A UK Multicentre Study.

Cardiovascular and interventional radiology·2026
Same author

Nutritional and lifestyle supportive care recommendations for management of obesity with GLP-1 - based therapies: An expert consensus statement using a modified Delphi approach.

Obesity pillars·2026
Same author

Pictorial review of the use of percutaneous mechanical thromboaspiration in peripheral vascular occlusions.

Clinical radiology·2025

Macrophages from mice infected with Echinococcus multilocularis suppressed immune responses. This immune suppression could be induced by Echinococcus multilocularis culture supernatant, affecting accessory cell function.

Area of Science:

  • Immunology
  • Parasitology
  • Cell Biology

Background:

  • Echinococcus multilocularis infection can alter host immune responses.
  • Macrophages act as accessory cells in modulating lymphocyte activity.

Purpose of the Study:

  • To investigate the impact of Echinococcus multilocularis infection on the accessory function of peritoneal macrophages.
  • To determine if Echinococcus multilocularis culture supernatant can modify macrophage accessory function.

Main Methods:

  • Collection of peritoneal macrophages and splenic lymphocytes from normal and infected BALB/c mice.
  • Accessory cell function assay using varying numbers of macrophages with lymphocytes, stimulated by concanavalin A or E. multilocularis culture supernatant.
  • In vivo induction of accessory cell modification using E. multilocularis culture supernatant or FPLC fractions.

Related Experiment Videos

Main Results:

  • Macrophages from Echinococcus multilocularis-infected mice suppressed concanavalin A- and E. multilocularis culture supernatant-driven lymphocyte transformation.
  • In vivo administration of E. multilocularis culture supernatant or its fractions modified accessory cell function.
  • Lymphocyte sensitivity to accessory cell signals increased after incubation with E. multilocularis culture supernatant.

Conclusions:

  • Peritoneal macrophages from Echinococcus multilocularis-infected mice exhibit suppressed accessory cell function.
  • Echinococcus multilocularis infection and its components can modulate host immune cell interactions.
  • These findings suggest a mechanism by which Echinococcus multilocularis evades host immunity.