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Updated: Jul 11, 2026

08:39
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
PLASMA PROTHROMBIN CONCENTRATION IN DOGS GIVEN 3,3'-METHYLENEBIS(4- HYDROXYCOUMARIN) AND PURIFIED BEEF PROTHROMBIN
Abstract:
Purified beef prothrombin will antidote the hypoprothrombinemia induced in dogs by oral administration of 3,3'-methylenebis (4-hydroxyeoumarin). If the hypothesis is proven that this chemical compound acts only by preventing the production of prothrombin in the liver then the life of injected beef prothrombin is probably of the same duration as that of the dog's own plasma prothrombin; namely, 2 to 3 days.
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