Related Experiment Video

Updated: Aug 19, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Pharmacologic interventions aimed at preventing the biologic effects of endotoxin

C A Sable1, B Wispelwey

  • 1Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville.

Infectious Disease Clinics of North America
|December 1, 1991
PubMed

Insights

Understanding septic shock pathogenesis has spurred new therapies. However, while some show promise, definitive recommendations are pending, with varying success rates post-septicemia onset.

Area of Science:

  • Critical Care Medicine
  • Pathophysiology
  • Pharmacology

Background:

  • Septic shock pathogenesis and pathophysiology are increasingly understood.
  • This has driven the development of potential adjunctive therapies.

Purpose of the Study:

  • To evaluate promising adjunctive therapies for septic shock.
  • To assess the efficacy of these agents in different treatment timings.

Main Methods:

  • Review of experimental settings and clinical evaluations of adjunctive therapies.
  • Analysis of treatment success based on timing relative to sepsis onset.

Main Results:

  • Several agents demonstrate promise in experimental models.
  • Definitive recommendations for clinical use are not yet established.
  • Therapies show greater benefit when administered before sepsis onset compared to after septicemia develops.

Conclusions:

  • While adjunctive therapies for septic shock are evolving, further research is needed.
  • Current evidence does not support definitive recommendations for widespread use.
  • Timing of intervention is a critical factor in therapeutic success.

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