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Liquid chromatography in 1982.

D H Freeman

    Science (New York, N.Y.)
    |October 15, 1982
    PubMed
    Summary
    This summary is machine-generated.

    High-speed liquid chromatography (LC) utilizes advanced instruments for difficult separations. Modern LC techniques with bonded phase particles and controlled liquid phases offer routine, efficient chemical analysis.

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    Area of Science:

    • Analytical Chemistry
    • Separation Science

    Background:

    • Classical liquid chromatography (LC) has evolved significantly over the past 15 years.
    • Advances in instrumentation have enabled high-speed separations.

    Purpose of the Study:

    • To highlight the advancements in liquid chromatography techniques.
    • To emphasize the widespread adoption and impact of modern LC.

    Main Methods:

    • Utilizing liquid chromatography instruments with automated controls and sensitive detectors.
    • Employing small, porous, "bonded phase" particles to optimize sorptive effects.
    • Controlling chemical selectivity through manipulation of the liquid phase.

    Main Results:

    • Difficult separations are now achievable routinely.

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  • Bonded phase particles enhance sorptive effects for better separations.
  • Liquid phase control refines chemical selectivity.

    • Conclusions:

    • Modern liquid chromatography techniques are easily learned and widely accepted.
    • Liquid chromatography is the fastest-growing area in chemical instrumentation.