Jove
Visualize
Contact Us

Related Experiment Videos

Nonimmunological host defenses: a review.

C A Apffel

    Cancer Research
    |May 1, 1976
    PubMed
    Summary

    The body possesses diverse non-immunological defenses against cancer, including containment of transformed cells and surveillance to prevent carcinogenesis. Antioxidants and detoxification enzymes play key roles in these protective mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatment of childhood diarrhea with pectin-carrying plant foods.

    La Presse medicale·2010
    Same author

    Microsomal aspects of carcinogenesis and neoplasia.

    Medical hypotheses·1979
    Same author

    Opposite effects of dextrans substituted with sulfhydryls or mercury on tumor growth.

    Cancer research·1979
    Same author

    The endoplasmic reticulum membrane system and malignant neoplasia.

    Progress in experimental tumor research·1978
    Same author

    Tumor rejection in experimental animals treated with radioprotective thiols.

    Cancer research·1975
    Same author

    Tumor growth and disulfide reduction: possible dependence on protein-disulfide reductase.

    Journal of the National Cancer Institute·1973
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Cancer Research

    Background:

    • Non-immunological defense mechanisms are crucial for preventing and controlling cancer.
    • These defenses include cellular containment of transformed cells and surveillance to inhibit carcinogenesis.
    • Key players include chalones, oncolytic factors, antioxidants, and detoxification enzymes.

    Purpose of the Study:

    • To explore the diverse non-immunological defense mechanisms against cancer.
    • To elucidate the roles of thiol oxidation, antioxidants, and detoxification systems in cancer prevention.
    • To highlight the importance of these endogenous and exogenous factors in maintaining cellular homeostasis and preventing carcinogenesis.

    Main Methods:

    • Review of existing literature on non-immunological anti-cancer defenses.
    • Analysis of biochemical pathways involving thiol:disulfide ratios, free radicals, and antioxidant activity.
    • Examination of the role of microsomal enzymes in carcinogen detoxification.

    Main Results:

    • Autoxidation of thiols and disulfide formation can lead to tumor cell destruction via reactive oxygen species.
    • Antioxidants inhibit free radical processes implicated in carcinogenesis, acting as surveillance agents.
    • Microsomal enzyme activity, influenced by diet, contributes to carcinogen detoxification.

    Conclusions:

    • Non-immunological defenses are vital, encompassing containment and surveillance strategies.
    • Thiol redox state and antioxidant activity are critical for cellular defense and cancer prevention.
    • Dietary factors and inducers can modulate detoxification systems, impacting cancer risk.

    Related Experiment Videos