Related Experiment Video
Updated: Jul 11, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Prevention and management of pain in the neonate. An update
Insights
Preventing pain in neonates is crucial, especially for premature infants at high risk for neurodevelopmental issues. Implementing comprehensive pain management programs in NICUs is essential for infant well-being.
Area of Science:
- Neonatal care
- Pediatric pain management
- Neurodevelopmental outcomes
Background:
- Repeated painful exposures in neonates can lead to adverse neurodevelopmental consequences.
- Premature infants, particularly the smallest and sickest, face the highest risk of pain exposure in the NICU.
- Current knowledge gaps exist regarding optimal neonatal pain prevention and relief strategies.
Purpose of the Study:
- To emphasize the critical need for pain prevention in neonates.
- To highlight the underuse of proven, safe therapies for routine painful procedures.
- To advocate for the implementation of comprehensive neonatal pain-prevention programs.
Main Methods:
- Review of existing knowledge on neonatal pain.
- Identification of effective pharmacologic and nonpharmacologic pain management therapies.
- Analysis of strategies for pain assessment and procedural modification.
Main Results:
- Proven and safe pain prevention therapies are underutilized in routine neonatal care.
- Neonates at highest risk for neurodevelopmental impairment are also most exposed to painful stimuli.
- Effective pain management is achievable through a multi-faceted approach.
Conclusions:
- All healthcare facilities caring for neonates must establish robust pain-prevention programs.
- Programs should include pain assessment, procedural minimization, and effective use of therapies.
- Eliminating pain during major procedures is a critical goal for neonatal care.
Abstract:
The prevention of pain in neonates should be the goal of all caregivers, because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest and sickest) are also those most likely to be exposed to the greatest number of painful stimuli in the NICU. Although there are major gaps in our knowledge regarding the most effective way to prevent and relieve pain in neonates, proven and safe therapies are currently underused for routine minor yet painful procedures. Every health care facility caring for neonates should implement an effective pain-prevention program, which includes strategies for routinely assessing pain, minimizing the number of painful procedures performed, effectively using pharmacologic and nonpharmacologic therapies for the prevention of pain associated with routine minor procedures, and eliminating pain associated with surgery and other major procedures.
More Related Videos
Related Concept Videos
Analgesia and Pain Management
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Peripheral Artery Disease V: Postoperative Nursing Management
Parenteral Anesthetics: Overview
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Peripheral Artery Disease IV: Nursing Management

