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Related Experiment Video

Updated: Jul 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Poor prognosis childhood cancers].

Dominique Valteau-Couanet¹, Véronique Minard

¹Département de pédiatrie, institut Gustave-Roussy, 94805 Villejuif Cedex. valteau@igr.fr

La Revue Du Praticien

|September 12, 2007

Summary

High-dose chemotherapy with stem cell transplant improves outcomes for children with metastatic neuroblastoma and Ewing tumors, despite high toxicity. This approach offers a better prognosis for these aggressive childhood cancers.

Area of Science:

Pediatric Oncology
Cancer Therapeutics
Hematopoietic Stem Cell Transplantation

Context:

Metastatic neuroblastoma (stage IV) and Ewing tumors are aggressive childhood cancers with poor prognoses.
Conventional chemotherapy is often insufficient for cure in these advanced-stage pediatric malignancies.
High-dose chemotherapy with autologous peripheral blood stem cell transplantation is a salvage strategy for patients with good partial remission.

Purpose:

To summarize the role and outcomes of high-dose chemotherapy with autologous peripheral blood stem cell transplantation in treating poor prognosis childhood cancers.
To highlight the challenges and benefits of this intensive treatment modality.

Summary:

Stage IV neuroblastomas and metastatic Ewing tumors are chemosensitive but not curable with standard chemotherapy.

Related Experiment Videos

Last Updated: Jul 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation is utilized for patients achieving partial remission.

While toxic, this procedure is manageable and has led to improved prognoses.

Impact:

This intensive treatment strategy offers improved survival and prognosis for children with otherwise incurable metastatic cancers.
Advances in stem cell transplantation contribute to better management of high-risk pediatric malignancies.
Further research may focus on mitigating toxicity while enhancing efficacy in pediatric cancer care.