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Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine
Franco de Conno1, Augusto Caraceni, Cinzia Martini
1Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, 20133 Milan Italy Department of Radiology, National Cancer Institute of Milan, 20133 Milan Italy Palliative Care Unit, USSL 75 / IV, 20143 Milan Italy.
Pain
|December 1, 1991
Abstract:
We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.
Insights
High-dose subarachnoid morphine can cause myoclonus and hyperalgesia. This case report discusses the potential pathophysiology of these morphine-induced side effects.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Subarachnoid morphine is used for pain management.
- High doses may lead to adverse neurological events.
- Myoclonus and hyperalgesia are potential complications.