Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptive evolution of conserved noncoding elements in mammals.

Su Yeon Kim1, Jonathan K Pritchard

  • 1Department of Statistics, The University of Chicago, Chicago, Illinois, USA. skim@galton.uchicago

Plos Genetics
|September 12, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes.

Genetics·2026
Same author

Diabetes reprograms brain and systemic immune landscapes to impair repair after injury.

Molecular brain·2026
Same author

<i>Phellodendron amurense</i> Leaf Extract Inhibits Rhabdovirus Infection by Targeting Early Stages of Viral Entry.

Pathogens (Basel, Switzerland)·2026
Same author

Molecular and Phenotypic Characterization of Multidrug-Resistant <i>Aspergillus fumigatus</i> Clinical Isolates in Republic of Korea.

Journal of fungi (Basel, Switzerland)·2026
Same author

Genetic variants affect diurnal glucose levels throughout the day.

Nature communications·2026
Same author

Development of a SYBR Green-based quantitative PCR assay for the detection of <i>Undaria pinnatifida</i> and <i>Endarachne binghamiae</i> using chloroplast markers in processed seaweed products.

Food science and biotechnology·2026
Same journal

Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation.

PLoS genetics·2026
Same journal

Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program.

PLoS genetics·2026
Same journal

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same journal

Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans.

PLoS genetics·2026
Same journal

Multiple instance fine-mapping: Predicting causal regulatory variants with a deep sequence model.

PLoS genetics·2026
Same journal

Nuclear ubiquitin-conjugating enzyme TrUbc4 and F-box protein TrFwd1-mediated modification of Cre1 in Trichoderma reesei establishes a regulatory mechanism for carbon catabolite repression.

PLoS genetics·2026
See all related articles

Most conserved noncoding elements (CNCs) evolve under consistent constraint, but 32% show rate variations. A subset accelerated, suggesting bursts of adaptive evolution in these important genomic regions.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Conserved noncoding elements (CNCs) are abundant in vertebrate genomes, but their functions are largely unknown.
  • Understanding the evolutionary dynamics of CNCs is crucial for deciphering their roles.

Purpose of the Study:

  • To develop and apply a statistical method to identify conserved noncoding elements (CNCs) with significant evolutionary rate variation.
  • To investigate the patterns and potential adaptive evolution of CNCs across mammalian genomes.

Main Methods:

  • Development of the "shared rates test," a statistical method to detect variations in substitution rates across phylogenetic tree branches.
  • Application of the shared rates test to alignments of 98,910 CNCs from human, chimpanzee, dog, mouse, and rat genomes.

Related Experiment Videos

Main Results:

  • Approximately 68% of CNCs followed a basic model of constraint.
  • About 32% of CNCs exhibited significant rate variations, including accelerations and decelerations on specific branches.
  • A subset of these variable CNCs showed rates significantly faster than the neutral rate, indicating adaptive evolution.

Conclusions:

  • Conserved noncoding elements (CNCs) display diverse evolutionary dynamics, with a notable fraction undergoing adaptive evolution.
  • Adaptive evolution in CNCs appears to occur in sporadic, short bursts.
  • Identified CNCs represent promising targets for future functional studies on adaptation.