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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Related Experiment Video

Updated: Jul 11, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Mannose binding lectin gene polymorphisms and asthma.

X Wang1, J Saito, Y Tanino

  • 1Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima City, Japan.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|September 12, 2007
PubMed
Summary

Mannose-binding lectin (MBL) levels and MBL2 gene variations do not appear to be linked to asthma development or severity in the Japanese adult population studied. Further research is needed to fully understand MBL

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Last Updated: Jul 11, 2026

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Immunology
  • Genetics
  • Respiratory Medicine

Background:

  • Bronchial asthma is a chronic airway inflammatory disease.
  • The complement system, particularly Mannose-binding lectin (MBL), is implicated in various immune disorders.
  • MBL plays a key role in complement activation pathways.

Purpose of the Study:

  • To investigate the association between MBL2 polymorphisms and plasma MBL levels with asthma.
  • To determine if MBL influences asthma phenotype, including severity and pulmonary function.

Main Methods:

  • Analysis of MBL2 polymorphisms (allele B, H/L, Y/X) and plasma MBL levels.
  • Study population comprised 232 healthy Japanese adults and 579 asthmatics.
  • Correlation analysis with serum IgE, pulmonary function, and asthma severity.

Main Results:

  • MBL2 polymorphisms independently affect serum MBL levels.
  • No significant differences in MBL2 genotype distribution or plasma MBL concentrations were found between asthmatics and controls.
  • MBL levels and genotype showed no significant relationship with asthma severity, IgE levels, or pulmonary function.

Conclusions:

  • MBL2 polymorphisms influence plasma MBL levels but are not associated with the asthma phenotype.
  • Plasma MBL levels are not a significant risk factor or marker for asthma in this population.