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Related Experiment Video

Updated: Jul 11, 2026

Transient Middle Cerebral Artery Occlusion Model of Stroke

Transient Middle Cerebral Artery Occlusion Model of Stroke

Published on: August 11, 2023

Sex differences in stroke evaluations in the Ischemic Stroke Genetics Study.

Thabele M Leslie-Mazwi¹, Thomas G Brott, Robert D Brown

¹Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|September 12, 2007

Summary

This study found no significant sex differences in diagnostic test utilization for ischemic stroke patients in a specialized stroke center. Tertiary stroke centers may help reduce evaluation biases in stroke diagnosis.

Related Experiment Videos

Last Updated: Jul 11, 2026

Transient Middle Cerebral Artery Occlusion Model of Stroke

Transient Middle Cerebral Artery Occlusion Model of Stroke

Published on: August 11, 2023

Area of Science:

Neurology
Medical Diagnostics
Epidemiology

Background:

Previous studies indicate sex disparities in the evaluation of patients experiencing ischemic stroke.
These disparities may impact the accuracy of diagnosing different ischemic stroke subtypes.
This research specifically examined sex differences within the Ischemic Stroke Genetics Study (ISGS).

Purpose of the Study:

To investigate potential sex-based differences in diagnostic test utilization among ischemic stroke patients.
To determine if tertiary stroke centers mitigate sex bias in stroke evaluation.

Main Methods:

The Ischemic Stroke Genetics Study (ISGS) enrolled 505 patients (45% women) with first-ever ischemic stroke.
This prospective, case-control genetic association study was conducted at 5 US tertiary stroke centers.
Diagnostic tests performed during routine medical care were systematically recorded for all participants.

Main Results:

No significant sex differences were observed in the performance rates of key diagnostic tests, including brain CT, MRI, ECG, echocardiography, cervical arterial imaging, and intracranial vascular imaging.
Women were older at the time of stroke onset compared to men (66.6 vs. 61.9 years, P = .001).
While not statistically significant, women showed slightly higher rates of echocardiography and intracranial vascular imaging.

Conclusions:

The findings suggest that the utilization of major diagnostic tests for ischemic stroke is comparable between men and women within the ISGS cohort.
Specialized tertiary stroke centers appear to minimize sex-based biases in diagnostic evaluations for stroke patients.
This indicates a potential model for equitable stroke care and diagnosis.