Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human oocyte cryopreservation.

Debra A Gook1, David H Edgar

  • 1Reproductive Services/Melbourne IVF, Royal Women's Hospital, 132 Grattan Street, Carlton, Victoria 3053, and Department of Obstetrics and Gynaecology, University of Melbourne, Australia. debra.gook@rwh.org.au

Human Reproduction Update
|September 12, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is the time right for transplanting immature testicular tissue or cells to restore male fertility? Expert perspectives on clinical implementation of autotransplantation of cryopreserved testicular tissue or cells for fertility restoration.

Best practice & research. Clinical obstetrics & gynaecology·2025
Same author

Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue.

Reproduction (Cambridge, England)·2020
Same author

Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation.

Fertility and sterility·2019
Same author

Cryopreservation of female reproductive potential.

Best practice & research. Clinical obstetrics & gynaecology·2018
Same author

Chapter 9 Slow Freezing and Thawing of Human Cleavage Stage Embryos.

Methods in molecular biology (Clifton, N.J.)·2017
Same author

Chapter 12 Human Ovarian Tissue Slow Freezing.

Methods in molecular biology (Clifton, N.J.)·2017
Same journal

Clinical outcomes and euploidy rates of embryos derived from zygotes with nonpronuclear (0PN) and monopronuclear (1PN) in IVF or ICSI cycles: a systematic review and meta-analysis.

Human reproduction update·2026
Same journal

Sperm mitochondrial DNA copy number: a marker of male fertility and reproductive success.

Human reproduction update·2026
Same journal

Embryo-derived extracellular vesicles and their potential as biomarkers for embryo quality during IVF: a systematic review.

Human reproduction update·2026
Same journal

Endometriosis and ovarian cancer: epidemiological evidence, molecular insights, and clinical decision-making.

Human reproduction update·2026
Same journal

Maternal genetic variants associated with aneuploid conception: a narrative review.

Human reproduction update·2026
Same journal

Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.

Human reproduction update·2026
See all related articles

Oocyte cryopreservation in assisted reproduction has advanced slowly due to safety concerns. Newer vitrification methods show promise, but more research is needed to confirm clinical efficiency and safety.

Area of Science:

  • Reproductive Medicine
  • Cryobiology

Background:

  • Oocyte cryopreservation's clinical role in assisted reproduction evolved slowly due to safety and efficacy concerns.
  • Early studies in the 1990s addressed some concerns, increasing adoption but highlighting perceived inefficiencies.
  • Improved methods like elevated sucrose concentrations and sodium-depleted media have not shown proven clinical benefits.

Purpose of the Study:

  • To review the evolution and current status of oocyte cryopreservation techniques in assisted reproduction.
  • To assess the efficacy and safety of different oocyte cryopreservation methods.
  • To identify limitations in current research and clinical practice.

Main Methods:

  • Review of historical development and scientific literature on oocyte cryopreservation.

Related Experiment Videos

  • Analysis of reported outcomes from various cryopreservation techniques, including slow freezing and vitrification.
  • Examination of factors influencing clinical efficiency and safety assessments.

    • Main Results:

    • Vitrification techniques have led to live births, but safety data is limited.
    • Despite improvements, well-controlled studies demonstrating enhanced clinical outcomes are lacking for various methods.
    • Limited data and legal restrictions in some regions hinder objective comparisons between techniques.

    Conclusions:

    • Oocyte cryopreservation has progressed, but robust evidence for improved clinical efficiency and safety of newer methods is still needed.
    • Vitrification shows potential, but further basic research and well-controlled clinical trials are essential.
    • Objective assessment of oocyte cryopreservation techniques is hampered by small sample sizes and regulatory factors.