Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interhospital variation in Medicare spending for infections after coronary artery bypass grafting and surgical aortic valve replacement.

JTCVS open·2026

Same author

Humanistic Machines: Designing Devices for People With Heart Failure With a Focus on Multidisciplinary Human Factors Research.

JACC. Heart failure·2026

Same author

The Ninth Annual STS-Pedimacs Report: Pediatric VAD Outcomes and the Expanding Role of Biventricular Support.

The Annals of thoracic surgery·2026

Same author

Aortic insufficiency and right heart failure in patients treated with durable left ventricular assist devices after preoperative support with microaxial flow devices.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Same author

Statewide Quality Collaborative As a Forum for Change: Promoting Adoption of Multiarterial Grafting in Coronary Artery Bypass Graft Surgery.

The Annals of thoracic surgery·2026

Same author

Correction: Association Between Cardiac Rehabilitation and 1-Year Mortality by Frailty Level in Medicare Beneficiaries.

Circulation. Population health and outcomes·2026

Search research articles

Related Experiment Video

Updated: May 9, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices.

Jonathan Haft¹, William Armstrong, David B Dyke

¹Section of Cardiac Surgery, University of Michigan Health System, Ann Arbor, MI 48109-5864, USA.

|September 14, 2007

Summary

Continuous-flow rotary pumps and pulsatile pumps offer similar exercise capacity for heart failure patients. However, pulsatile pumps provide superior left ventricular volume unloading, without impacting early exercise performance.

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

Area of Science:

Cardiology
Biomedical Engineering
Mechanical Circulatory Support

Background:

Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support.
The efficacy of axial continuous-flow pumps compared to pulsatile, volume displacement pumps for left ventricular unloading and exercise performance is not well-studied.

Purpose of the Study:

To compare the efficacy of axial continuous-flow rotary pumps versus pulsatile, volume displacement pumps in terms of left ventricular unloading and exercise performance.

Main Methods:

Thirty-four patients received either a pulsatile (HeartMate XVE) or axial continuous-flow (HeartMate II) pump.
Patients were evaluated preoperatively and at 3 months postoperatively using right heart catheterization, echocardiography, and cardiopulmonary exercise testing.

Main Results:

Both pump types significantly increased cardiac output and reduced pulmonary pressures.
Exercise capacity (peak VO2) at 3 months was similar between the HeartMate XVE and Heart II groups.
The HeartMate XVE demonstrated significantly greater reductions in left ventricular end-diastolic volume, end-systolic volume, and mitral valve regurgitant volume compared to the HeartMate II.

Conclusions:

Both HeartMate XVE and HeartMate II provide equivalent hemodynamic support and early exercise capacity.
The pulsatile HeartMate XVE achieves greater left ventricular volume unloading compared to the axial continuous-flow HeartMate II.
Left ventricular pressure and volume unloading characteristics do not influence early exercise performance between these pump designs.