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Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension

Begoña López1, José M Castellano, Arantxa González

  • 1Division of Cardiovascular Sciences, University Clinic, University of Navarra, Pamplona, Spain.

Hypertension (Dallas, Tex. : 1979)
|September 12, 2007
PubMed

Insights

Elevated cardiotrophin-1 levels correlate with inappropriate left ventricular mass in hypertension. This cytokine may drive excessive heart muscle growth in hypertensive patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • Inappropriate left ventricular mass (ILVM) is linked to increased cardiovascular risk in hypertension.
  • Cardiotrophin-1 (CT-1) is a cytokine implicated in cardiomyocyte hypertrophy.

Purpose of the Study:

  • To investigate the relationship between plasma cardiotrophin-1 levels and ILVM in never-treated essential hypertension patients.
  • To assess changes in CT-1 and ILVM after antihypertensive treatment.

Main Methods:

  • 118 never-treated hypertensive patients and 45 normotensive controls were studied.
  • Left ventricular mass was assessed using predicted values based on stroke work, sex, and height.
  • Plasma CT-1 was measured using ELISA; ILVM was defined as observed/predicted LVM >128%.

Main Results:

  • Patients with ILVM had significantly higher plasma CT-1 levels than those with appropriate LVM and controls (P<0.001).
  • A direct correlation was observed between CT-1 and the LVM ratio (r=0.330, P<0.001).
  • After treatment, CT-1 levels decreased when ILVM regressed and increased when it persisted, irrespective of blood pressure reduction.

Conclusions:

  • Elevated plasma cardiotrophin-1 is associated with inappropriate left ventricular mass in essential hypertension.
  • These findings suggest cardiotrophin-1 may play a role in the pathogenesis of hypertensive cardiac hypertrophy.

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