Related Experiment Video
Updated: Jul 11, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Grafting of tooth extraction socket with inorganic bovine bone or bioactive glass particles: comparative histometric
Romeu Felipe Elias Calixto1, Juliana Mazzonetto Teófilo, Luiz Guilherme Brentegani
1Post-Graduate in Oral Rehabilitation, Dental School of Ribeirão Preto-USP, Brazil.
Purpose:
To compare histometrically, in rats, the bone healing after grafting the incisor extraction sockets with inorganic bovine bone or bioactive glass particles.
Material:
The volume fraction of grafted materials and alveolar healing components was estimated in histologic images at the end of the second and ninth weeks postoperatively by a differential point-counting method.
Results:
Both materials were histologically observed partially filling the cervical alveolar third and, although evoking neither a foreign body reaction nor a persisting inflammatory response, delayed new bone formation in trial areas around their particles. By the second week, the delay in bone healing was more pronounced in the animals grafted with inorganic than in those grafted with bioactive glass, and an opposing result was observed during a 9-week period.
Conclusion:
Both inorganic bovine bone and bioactive glass particles grafted in the incisor extraction sockets of rats delayed new bone formation, and the degree of impairment resulted from a combination of factors such as type of material and phase of the reparation process.
