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Related Experiment Video

Updated: Jul 11, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

Correlation between serum lactate dehydrogenase and stem cell mobilization.

K Egan1, V Singh, A Gidron

  • 1Division of Hematology/Oncology, Hematopoietic Stem Cell Transplant Program, Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

Bone Marrow Transplantation
|September 12, 2007
PubMed
Summary

Elevated serum lactate dehydrogenase (LDH) levels strongly correlate with higher peripheral blood CD34+ cell counts, indicating good stem cell mobilization for apheresis. This finding suggests pre-apheresis LDH levels can predict successful stem cell collection.

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Area of Science:

  • Hematology
  • Transplantation Immunology
  • Clinical Chemistry

Background:

  • Stem cell apheresis is a critical procedure for hematopoietic stem cell transplantation.
  • Predicting the success of stem cell mobilization and collection is essential for patient outcomes.
  • Previous observations suggested a link between serum lactate dehydrogenase (LDH) levels and stem cell yield.

Purpose of the Study:

  • To investigate the correlation between pre-apheresis serum lactate dehydrogenase (LDH) levels and the absolute peripheral blood CD34+ cell count (PBCD34).
  • To determine if LDH is a reliable predictor of successful stem cell mobilization for apheresis procedures.

Main Methods:

  • Retrospective analysis of data from 540 donors undergoing 650 stem cell apheresis procedures (87% autologous, 13% allogeneic).

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Related Experiment Videos

Last Updated: Jul 11, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
06:18

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Published on: June 21, 2018

  • Statistical analysis including correlation coefficients (r) and p-values to assess relationships between LDH, PBCD34, leukocytes, and platelets.
  • Multivariate regression analysis to identify significant predictors of PBCD34.

    • Main Results:

    • A very strong positive correlation was found between serum LDH levels and PBCD34 (r=0.54; P<10(-48)).
    • Serum LDH was the only significant factor correlating with PBCD34 in multivariate analysis.
    • Elevated LDH levels were associated with significantly higher PBCD34 (median 53 vs. 11; P<0.00001), regardless of collection type (autologous r=0.54, allogeneic r=0.41).

    Conclusions:

    • Elevated serum lactate dehydrogenase is a strong and independent predictor of good stem cell mobilization.
    • Pre-apheresis LDH measurement can be a valuable tool to anticipate successful stem cell collection.
    • It is reasonable to initiate apheresis when elevated LDH levels are observed, suggesting adequate stem cell mobilization.