Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infection and glomerulonephritis.

Saraladevi Naicker1, June Fabian, Sagren Naidoo

  • 1Division of Nephrology, University of the Witwatersrand, Johannesburg Hospital, 7 York Road, Parktown, Johannesburg, Gauteng, 2193, South Africa. Saraladevi.Naicker@wits.ac.za

Seminars in Immunopathology
|September 12, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond consent: community engagement, benefit sharing and reciprocity in kidney genomics research.

Nature reviews. Nephrology·2026
Same author

Chronic kidney disease, complex conditions, and advancing therapeutics: new hope and challenges.

Lancet (London, England)·2026
Same author

Hypertension Incidence and Its Risk Factors in a Longitudinal Cohort of Middle-Aged Men and Women Living in Urban South Africa.

Journal of clinical hypertension (Greenwich, Conn.)·2026
Same author

Prevalence of CKD Among Adults in Africa: A Systematic Review and Meta-Analysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

From urban NPOs to rural knowledge networks: applying benefit-sharing models to African genomics research.

Nature communications·2026
Same author

Through Awareness to Action: Overcoming Gender Inequities in Academic Medicine and Nephrology.

Kidney international reports·2026
Same journal

PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker.

Seminars in immunopathology·2026
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
See all related articles

Glomerular injury often stems from immune responses, involving circulating or in situ immune complex formation. Infections like HIV and viral hepatitis can trigger diverse, challenging-to-treat glomerulonephritides.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Glomerular injury, a key feature in kidney disease, typically involves immune-mediated processes.
  • Morphological presentations range from minimal change disease to severe crescentic glomerulonephritis.
  • Immune deposits in glomeruli form via circulating immune complexes or in situ formation.

Purpose of the Study:

  • To explore the diverse mechanisms of glomerular injury, focusing on immune-mediated pathways.
  • To review the spectrum of renal pathology associated with infections like HIV, Hepatitis B, and C.
  • To highlight the challenges in treating these virus-associated glomerulonephritides.

Main Methods:

  • Review of existing literature on glomerular injury and immune complex formation.

Related Experiment Videos

  • Analysis of pathogenetic mechanisms in various glomerulonephritides.
  • Examination of glomerular manifestations in HIV and viral hepatitis infections.

    • Main Results:

    • Glomerular injury mechanisms include deposition of circulating immune complexes and in situ formation.
    • In situ immune complex formation via autoimmune reactions is increasingly recognized.
    • HIV, Hepatitis B, and C infections are linked to diverse glomerulonephritides, some non-immune-complex-mediated.

    Conclusions:

    • Immune-mediated mechanisms are central to glomerular injury, with evolving understanding of in situ complex formation.
    • Viral infections significantly contribute to glomerulonephritis development.
    • Effective therapeutic strategies for virus-associated glomerulonephritis remain a critical unmet need.