Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Glial Cells01:04

Glial Cells

Overview
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting purinergic receptors in glioblastoma with nanobody-displaying AAV vectors.

Neuropharmacology·2026
Same author

Therapeutic vaccination for glioblastoma elicited by retargeted oncolytic herpes virus.

Journal for immunotherapy of cancer·2026
Same author

Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription.

Acta neuropathologica·2025
Same author

miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues.

Cardiovascular research·2024
Same author

Early clonal extinction in glioblastoma progression revealed by genetic barcoding.

Cancer cell·2023
Same author

Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumors.

Journal of neuro-oncology·2023

Related Experiment Video

Updated: Jul 11, 2026

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats
06:52

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats

Published on: February 9, 2024

Radial glia and neural stem cells.

Paolo Malatesta1, Irene Appolloni, Filippo Calzolari

  • 1Dipartimento di Oncologia, Biologia e Genetica, Università degli Studi di Genova, Largo Rosanna Benzi 10, 16132, Genoa, Italy. paolo.malatesta@unige.it

Cell and Tissue Research
|September 12, 2007
PubMed
Summary

Radial glia, once thought only structural, are now recognized as key neural progenitors in the central nervous system. These cells generate neurons during development and give rise to neural stem cells for adult neurogenesis.

More Related Videos

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
12:38

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Related Experiment Videos

Last Updated: Jul 11, 2026

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats
06:52

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats

Published on: February 9, 2024

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
12:38

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Research

Background:

  • Radial glia were traditionally viewed as structural guides for migrating neurons.
  • Recent research has redefined radial glia as crucial neural progenitors.

Purpose of the Study:

  • To explore the multifaceted role of radial glia in neurogenesis.
  • To investigate the heterogeneity and lineage potential of radial glia.
  • To understand the connection between embryonic radial glia and adult neural stem cells.

Main Methods:

  • Clonal analysis of radial glial cells.
  • Molecular marker expression profiling.
  • Comparative studies of embryonic and postnatal neurogenesis.

Main Results:

  • Radial glia are the primary source of neurons in regions like the cerebral cortex.
  • Radial glia are heterogeneous, containing both pluripotent and lineage-restricted progenitors.
  • A potential clonal link exists between embryonic radial glia and adult neural stem cells.

Conclusions:

  • Radial glia are dynamic progenitors essential for both embryonic and adult neurogenesis.
  • These cells exhibit stem cell characteristics throughout the central nervous system's lifespan.
  • Understanding radial glia is critical for regenerative medicine and neurological research.