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Updated: Jul 11, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand
Khanitha Pudhom1, Damrong Sommit, Nattida Suwankitti
1Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand. Khanitha.P@chula.ac.th
Abstract:
Three new cassane furanoditerpenoids ( 1- 3), together with 13 known cassane diterpenes ( 4- 16), were isolated from the EtOAc extract of the seed kernels of Caesalpinia bonduc. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1- 3 exhibited good antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum, while compound 4 was inactive. None of the compounds were cytotoxic against any of the tumor cell lines tested.
