Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Spongy Bone

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Radiation protection and procedures in the OR.

Radiologic technology·2008

Same author

Marfan syndrome.

Radiologic technology·2007

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Paget disease of bone.

Julie A Chaffins¹

¹G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi, USA.

Radiologic Technology

|September 13, 2007

Summary

Paget disease of bone, or osteitis deformans, is a common bone disorder causing abnormal bone remodeling. This localized condition affects one or more bones, leading to enlargement and deformity, with genetics and viral factors suspected as causes.

Area of Science:

Bone biology and pathology
Skeletal disorders
Genetics and virology

Background:

Paget disease of bone (osteitis deformans) is the second most prevalent bone disorder globally.
It is a localized condition, impacting specific bones rather than the entire skeleton.
Characterized by accelerated and abnormal bone remodeling, leading to enlarged and deformed bones, primarily in the axial skeleton.

Purpose of the Study:

To provide a comprehensive overview of Paget disease of bone.
To highlight its characteristics, prevalence, and affected skeletal regions.
To discuss the current understanding of its etiology, including genetic and viral factors.

Main Methods:

Literature review of Paget disease of bone.
Analysis of epidemiological data on bone disorders.

Related Experiment Videos

Last Updated: Jul 11, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Synthesis of research on the genetic and suspected viral causes of osteitis deformans.

Main Results:

Paget disease of bone is a significant skeletal disorder affecting bone remodeling.
The disease predominantly impacts the axial skeleton, causing bone enlargement and deformity.
While the exact cause remains unknown, genetic factors are confirmed, and viral influences are under investigation.

Conclusions:

Paget disease of bone is a common, localized skeletal disorder with distinct pathological features.
Understanding the genetic and potential viral underpinnings is crucial for future research.
Further investigation is needed to fully elucidate the etiology of osteitis deformans.