Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Deep brain stimulation.

Drew S Kern1, Rajeev Kumar

  • 1College of Medicine, University of Vermont, Burlington, Vermont, USA.

The Neurologist
|September 13, 2007
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) offers sustained, long-term benefits for movement disorders like Parkinson disease and essential tremor. This surgical treatment improves motor function, daily living, and quality of life, with ongoing research refining its efficacy and applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping neural representations of fine and gross upper-limb movements across dorsoventral subthalamic nucleus subregions in Parkinson's disease.

Journal of neural engineering·2026
Same author

Recruitment feasibility for deep brain stimulation compared to transcranial magnetic stimulation treatment trials for methamphetamine use disorder.

Addictive behaviors reports·2026
Same author

Development and acceptability of a deep brain stimulation surgery decision aid for Parkinson's disease.

Journal of Parkinson's disease·2026
Same author

Considerations for Initiation and Maintenance of Foslevodopa/Foscarbidopa for Advanced Parkinson's Disease.

Movement disorders clinical practice·2026
Same author

Bioequivalence of Foslevodopa/Foscarbidopa continuous subcutaneous infusion to arm, thigh, or flank versus abdomen in healthy and advanced Parkinson's disease individuals.

Clinical parkinsonism & related disorders·2026
Same author

Foslevodopa/Foscarbidopa in Younger Patients Earlier Within Advanced Parkinson's Disease: Post Hoc Analysis of a Randomized Trial.

Neurology and therapy·2025
Same journal

Artificial Intelligence in the Prehospital Stage of Stroke: Can Virtual Assistants Optimize Triage?

The neurologist·2026
Same journal

Looking Beyond the Midline: An Uncommon Etiology of Internuclear Ophthalmoplegia of Abduction Due to Cerebral Venous Thrombosis.

The neurologist·2026
Same journal

Commentary: Cervical Artery Dissection and Chiropractic Cervical Manipulation: Clarifying Association, Mechanism, and Interpretation.

The neurologist·2026
Same journal

Acute Spinal Cord Infarct Secondary to Fibrocartilaginous Embolism Treated With Tenecteplase.

The neurologist·2026
Same journal

Cervical Artery Dissection and Chiropractic​​​​​.

The neurologist·2026
Same journal

Oromandibular Dyskinesia Associated With Levofloxacin and Responsive to Low-Dose Oral Diazepam: A Case Report.

The neurologist·2026
See all related articles

Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Deep brain stimulation (DBS) has gained significant traction over the last 15 years for treating various neurologic conditions.
  • This review emphasizes movement disorder applications and efficacy, while also touching upon other current and emerging uses of DBS.

Purpose of the Study:

  • To review the efficacy and applications of Deep Brain Stimulation (DBS) in treating movement disorders.
  • To highlight optimal patient selection criteria and surgical targets for DBS procedures.

Main Methods:

  • Patient selection involves a multidisciplinary team assessing disability, cognitive health, and psychiatric status.
  • Review of existing literature on DBS efficacy for Parkinson disease, essential tremor, and dystonia.
  • Analysis of outcomes based on stimulation targets such as the subthalamic nucleus (STN), globus pallidus pars interna (GPi), and ventralis intermedius nucleus of the thalamus.

Related Experiment Videos

Main Results:

  • DBS of the STN and GPi significantly enhances motor performance, daily activities, and quality of life in advanced Parkinson disease.
  • STN DBS enables substantial reductions in antiparkinsonian medication.
  • Thalamic VIM nucleus stimulation provides effective, long-term relief for essential tremor, while GPi stimulation shows a typical 75% improvement in movement scores for primary dystonia.

Conclusions:

  • Deep brain stimulation is a proven surgical intervention for movement disorders, offering lasting therapeutic benefits.
  • Ongoing research aims to elucidate DBS mechanisms, enhance hardware, minimize side effects, and explore novel applications and targets.