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Updated: Feb 9, 2026

Zika Virus Specific Diagnostic Epitope Discovery
Published on: December 12, 2017
ORF virus infection in children: clinical characteristics, transmission, diagnostic methods, and future therapeutics
Edith R Lederman1, Connie Austin, Ingrid Trevino
1Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. erlederman@yahoo.com
Abstract:
Orf virus leads to self-limited, subacute cutaneous infections in children who have occupational or recreational contact with infected small ruminants. Breaches in the integument and contact with animals recently vaccinated for orf may be important risk factors in transmission. Common childhood behaviors are likely important factors in the provocation of significant contact (ie, bites) or in unusual lesion location (eg, facial lesions). Clinician recognition is important in distinguishing orf infection from life-threatening cutaneous zoonoses. Recently developed molecular techniques provide diagnostic precision and newer topical therapeutics may hasten healing.
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