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Related Concept Videos

Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
Microtubules and motor proteins exert two types of forces on...

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Related Experiment Video

Updated: Jul 11, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
06:39

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Chromosomal passengers: conducting cell division.

Sandrine Ruchaud1, Mar Carmena, William C Earnshaw

  • 1Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

Nature Reviews. Molecular Cell Biology
|September 13, 2007
PubMed
Summary

The chromosomal passenger complex (CPC) orchestrates cell division processes like mitosis and meiosis. This complex, containing Aurora-B kinase, is crucial for chromosome interactions and cell division accuracy.

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Last Updated: Jul 11, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
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Published on: March 14, 2018

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Mitosis and meiosis are fundamental cell division processes.
  • These processes require precise regulation of cellular activities.
  • The chromosomal passenger complex (CPC) is a key regulator in cell division.

Purpose of the Study:

  • To elucidate the functions of the chromosomal passenger complex (CPC).
  • To understand the role of CPC in mitosis and meiosis.
  • To highlight CPC as a dynamic research area.

Main Methods:

  • Studies involving the analysis of the chromosomal passenger complex (CPC).
  • Investigating the components of the CPC, including Aurora-B kinase, INCENP, survivin, and borealin.
  • Observational and experimental research on CPC functions.

Main Results:

  • The CPC plays a critical role in orchestrating cell division.
  • CPC is involved in chromosome-microtubule interactions.
  • CPC influences sister chromatid cohesion and cytokinesis.

Conclusions:

  • The chromosomal passenger complex (CPC) is essential for accurate mitosis and meiosis.
  • CPC functions are diverse, impacting multiple stages of cell division.
  • Research on CPC continues to be a rapidly advancing field in cell biology.