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[Cyclosporine and psoriasis].

J M Mazer1

  • 1Service de dermatologie, hôpital Bichat, Paris.

La Revue Du Praticien
|October 15, 1991
PubMed
Summary
This summary is machine-generated.

Low-dose cyclosporin effectively treats severe psoriasis with manageable side effects. Regular monitoring of blood pressure and creatinine is crucial for safe and beneficial outcomes in patients with resistant psoriasis.

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Area of Science:

  • Immunosuppressive therapy
  • Dermatology
  • Pharmacology

Context:

  • Severe and resistant psoriasis requires effective treatment options.
  • Cyclosporin is an established immunosuppressant with potential for psoriasis management.
  • Understanding dose-dependent side effects is critical for therapeutic use.

Purpose:

  • To evaluate the efficacy and safety of cyclosporin in severe and resistant psoriasis.
  • To determine optimal dosing strategies for managing psoriasis with cyclosporin.
  • To identify and mitigate key adverse events associated with cyclosporin treatment.

Summary:

  • Cyclosporin demonstrates efficacy in severe, resistant psoriasis cases.
  • Moderate doses (below 5 mg/kg/day) yield satisfactory clinical results.

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  • Key side effects, including hypertension and nephrotoxicity, are dose-dependent and reversible with dose reduction.

    • Impact:

    • Low-dose cyclosporin (initially 3 mg/kg/day) offers a significant advancement in treating severe psoriasis.
    • Regular monitoring of blood pressure and creatinine levels is essential for patient safety.
    • Cyclosporin provides a valuable therapeutic option when managed judiciously.