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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System
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Published on: May 5, 2018

Prenatal diagnosis of congenital complete heart block

Patrícia Costa1, Ana Carriço, Carla Ramalho

  • 1Serviço de Cardiologia Pediátrica, Centro de Diagnóstico Pré-natal, Hospital de São João, Porto, Portugal. patriciacmc@zmail.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|September 14, 2007
PubMed

Insights

Congenital complete heart block (CHB), a rare heart defect, affects 1 in 15,000 births. This case highlights CHB linked to maternal lupus, a common association with autoimmune diseases.

Area of Science:

  • Cardiology
  • Immunology
  • Pediatrics

Background:

  • Congenital complete heart block (CHB) is a rare cardiac conduction defect.
  • CHB incidence ranges from 1:15,000 to 1:22,000 live births.
  • Often associated with structural heart defects or maternal autoimmune conditions.

Observation:

  • This study details a case of CHB in an infant.
  • The infant's mother had systemic lupus erythematosus (SLE).
  • Previous cases and clinical experience with CHB were also reviewed.

Findings:

  • A strong association between CHB and maternal SLE was observed.
  • Maternal autoimmune disease is a significant risk factor for CHB.
  • Review of prior cases confirms this association.

Implications:

  • Early diagnosis and management of CHB are crucial.
  • Understanding the link with maternal autoimmune diseases can improve risk assessment.
  • Further research into the pathogenesis of CHB in relation to maternal autoimmunity is warranted.

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