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Diabetic Foot Ulcer

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Updated: Jul 11, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Diabetic foot ulcers--a comprehensive review.

¹Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Room 74026, 5th Floor, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong. pingcleung@cuhk.edu.hk

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

|September 14, 2007

Summary

Diabetic foot ulcers are a growing public health concern due to increasing diabetes mellitus incidence. Effective management requires careful assessment of ulcer depth and appropriate local treatments, including footwear off-loading for prevention.

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Last Updated: Jul 11, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Area of Science:

Podiatry
Endocrinology
Public Health

Background:

Diabetes mellitus incidence is rising globally, leading to increased complications.
Diabetic foot ulcers represent a significant public health challenge due to their prevalence.
Predisposing factors include abnormal foot pressures, deformities, trauma, vascular insufficiency, and neuropathy.

Purpose of the Study:

To review the management and prognostic factors of diabetic foot ulcers.
To highlight the importance of ulcer depth as a prognostic indicator.
To discuss various treatment modalities, from local care to surgical interventions.

Main Methods:

Review of existing literature on diabetic foot ulcer management.
Analysis of prognostic indicators for ulcer healing.
Discussion of treatment strategies including debridement, dressings, surgical options, and preventative measures.

Main Results:

Ulcer depth, involvement of deeper structures (tendons, ligaments, joints), and presence of gangrene are critical prognostic factors.
Local treatment involves debridement and dressings; innovative agents show limited 'miraculous' outcomes.
Surgical interventions range from simple skin grafting and minor amputations to complex flap coverages.

Conclusions:

Diabetic foot ulcer management is complex, requiring individualized treatment plans.
Limb salvage versus sacrifice decisions must consider functional outcomes and patient factors.
Off-loading footwear is crucial for both treatment and prevention of diabetic foot ulcers.