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Acute decrease of coronary flow after indomethacin delivery in newborn lambs.

Solweig Harling1, Gylfi Oskarsson, Saemundur Gudmundsson

  • 1Department of Paediatrics, University Hospital, Lund, Sweden. solweig.harling@med.lu.se

Acta Paediatrica (Oslo, Norway : 1992)
|September 14, 2007
PubMed
Summary

Indomethacin (IND) significantly reduced coronary flow velocity in premature lambs, increasing cardiac workload. Recovery time correlated with the extent of this coronary flow reduction.

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Area of Science:

  • Neonatal physiology
  • Cardiovascular pharmacology
  • Pediatric cardiology

Background:

  • Premature lambs are susceptible to cardiovascular changes.
  • Indomethacin (IND) is used in neonates but its effects on coronary flow are not fully understood.

Purpose of the Study:

  • To investigate the impact of indomethacin (IND) on coronary blood flow in premature lambs.

Main Methods:

  • Nine premature lambs were studied within their first day of life.
  • Coronary flow velocities in the left anterior descending artery (LAD) were measured using Doppler guide wire.
  • Measurements were taken before, during, and after intravenous IND administration (0.2 mg/kg).

Main Results:

  • Indomethacin (IND) increased systemic blood pressure and rate pressure product, indicating higher cardiac workload.

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  • A significant decrease in coronary average peak flow velocity was observed in all lambs.
  • The maximal reduction in coronary flow velocity was 52%, with a median of 26%.

    • Conclusions:

    • A bolus dose of indomethacin (IND) markedly decreased coronary flow velocity in premature lambs.
    • The recovery of coronary flow was directly proportional to the magnitude of the velocity reduction.