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Updated: Jul 11, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Polyhydroxyserratane triterpenoids from Diphasiastrum complanatum.

Jian Yan¹, Ping Yi, Baohui Chen

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, PR China.

|September 14, 2007

Summary

This study identified five novel serratane triterpenoids from Diphasiastrum complanatum (L.) Holub. These compounds, along with nine known analogs, were characterized using spectroscopic data, expanding our knowledge of plant-derived natural products.

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Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

Diphasiastrum complanatum (L.) Holub is a plant species known for its potential bioactive compounds.
Triterpenoids, a class of natural products, exhibit diverse pharmacological activities.
Investigating the chemical constituents of lesser-studied plants can lead to the discovery of novel compounds.

Purpose of the Study:

To isolate and characterize serratane triterpenoids from Diphasiastrum complanatum (L.) Holub.
To identify novel chemical entities within the plant's extract.
To contribute to the understanding of the phytochemical diversity of the Diphasiastrum genus.

Main Methods:

Extraction and isolation of compounds from Diphasiastrum complanatum (L.) Holub.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Extensive spectroscopic analysis, including NMR and Mass Spectrometry, for structural elucidation.

Comparison with known compounds and literature data for identification.

Main Results:

Five novel serratane triterpenoids were identified: serratane-3alpha,14alpha,15alpha,20beta,21beta,24,29-heptol (1), 3alpha,20beta,21beta-trihydroxyserrat-14-en-24-oic acid (2), 3beta,20beta,21beta-trihydroxyserrat-14-en-24-oic acid (3), 3alpha,20beta,21beta-trihydroxy-16-oxoserrat-14-en-24-oic acid (4), and 16-oxolyclanitin-29-yl E-4'-hydroxyl-3'-methoxycinnamate (5).
Nine known serratane triterpenoid analogs were also identified.
The structures were confirmed based on comprehensive spectroscopic data.

Conclusions:

The phytochemical investigation of Diphasiastrum complanatum (L.) Holub led to the discovery of new serratane triterpenoids.
This study expands the known chemical profile of serratane triterpenoids.
The identified compounds may serve as leads for future pharmacological studies.