Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

POEMS syndrome.

Angela Dispenzieri1

  • 1Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, United States. dispenzieri.angela@mayo.edu

Blood Reviews
|September 14, 2007
PubMed
Summary
This summary is machine-generated.

Early recognition of POEMS syndrome, a rare plasma cell disorder, is crucial for management. Key features include neuropathy, organomegaly, and skin changes, with sclerotic bone lesions often present.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.

Circulation·2018
Same author

Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

Nature reviews. Nephrology·2018
Same author

Staging systems use for risk stratification of systemic amyloidosis in the era of high-sensitivity troponin T assay.

Blood·2018
Same author

Overall survival of transplant eligible patients with newly diagnosed multiple myeloma: comparative effectiveness analysis of modern induction regimens on outcome.

Blood cancer journal·2018
Same author

Autologous Stem Cell Transplant for IgM-Associated Amyloid Light-Chain Amyloidosis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2018
Same author

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma.

American journal of hematology·2018
Same journal

Treating large B-cell lymphoma: Current strategies and unmet needs across community and academic settings.

Blood reviews·2026
Same journal

MRD in multiple myeloma: Moving from "minimal" to "measurable".

Blood reviews·2026
Same journal

PRISMA-based systematic review on iron stores in repeat blood donors.

Blood reviews·2026
Same journal

Artificial intelligence applications in thrombotic thrombocytopenic Purpura: A systematic review of diagnostic, risk stratification, and prognostic models.

Blood reviews·2026
Same journal

Antibacterial, antifungal and antiviral prophylaxis and vaccination strategies in adult patients with acute myeloid and promyelocytic leukemia: An expert panel consensus from the GIMEMA group.

Blood reviews·2026
Same journal

The Lebanese national patient blood management guidelines: A new page in the medical practice.

Blood reviews·2026
See all related articles

Area of Science:

  • Hematology
  • Neurology
  • Oncology

Background:

  • POEMS syndrome is a rare paraneoplastic syndrome linked to plasma cell dyscrasias.
  • It presents with a complex constellation of symptoms including neuropathy, organomegaly, endocrinopathy, and skin changes.
  • Elevated vascular endothelial growth factor (VEGF) levels are typically confirmatory.

Purpose of the Study:

  • To outline the diagnostic criteria for POEMS syndrome.
  • To discuss the management strategies for POEMS syndrome based on disease presentation.
  • To highlight the current mainstays of treatment and areas for future research.

Main Methods:

  • Review of clinical manifestations and diagnostic markers.
  • Analysis of treatment approaches for localized and diffuse disease.

Related Experiment Videos

  • Consideration of systemic therapies and emerging treatment modalities.

    • Main Results:

    • Over 95% of patients exhibit monoclonal lambda plasmacytoma or bone marrow infiltration.
    • Radiation therapy is the first-line treatment for dominant sclerotic plasmacytoma.
    • Systemic therapies including corticosteroids, alkylator therapy, and stem cell transplant are indicated for diffuse disease or lack of response to radiation.

    Conclusions:

    • Effective management of POEMS syndrome relies on prompt recognition of its diverse clinical features.
    • Treatment strategies should be tailored to the specific presentation, with radiation for localized lesions and systemic therapy for diffuse or refractory disease.
    • Further research is needed to define the role of novel therapies like anti-VEGF agents, while avoiding agents with known neurotoxicity.