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Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population

Iván Delgado-Enciso1, Friedman R Cepeda-Lopez, Elisa A Monrroy-Guizar

  • 1School of Medicine, Universidad de Colima, Colima, Col., Mexico. ivan_delgado_enciso@ucol.mx

Gynecologic and Obstetric Investigation
|September 14, 2007
PubMed
Abstract

Insights

The MMP-2 -1306C>T gene variant is linked to breast cancer (BC) risk in Mexican women. The CC genotype is more common in BC patients, particularly those diagnosed before age 50.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Matrix metalloproteinase-2 (MMP-2) is an enzyme involved in matrix protein degradation.
  • A specific single nucleotide polymorphism (SNP) at the -1306 position (C>T) in the MMP-2 gene has been associated with various cancers.
  • The role of this MMP-2 polymorphism in breast cancer (BC) development, especially in specific populations, requires further investigation.

Purpose of the Study:

  • To investigate the association between the MMP-2 -1306C>T polymorphism and the risk of developing breast cancer (BC).
  • To analyze the frequency of MMP-2 genotypes in a Mexican population with and without BC.

Main Methods:

  • Genotyping analysis was performed on 90 breast cancer patients and 96 healthy control subjects.
  • The study aimed to detect the presence and frequency of the MMP-2 -1306C>T polymorphism in these groups.

Main Results:

  • The CC genotype of the MMP-2 -1306C>T polymorphism was found significantly more often in breast cancer patients compared to controls (OR 2.15; 95% CI 1.1-4.1).
  • This CC genotype association was particularly strong in younger patients (≤50 years at diagnosis) (OR 2.66; 95% CI 1.04-6.96).

Conclusions:

  • The MMP-2 -1306C>T polymorphism appears to be a significant genetic risk factor for breast cancer development in the studied Mexican population.
  • The CC genotype confers an elevated risk, especially for women diagnosed with breast cancer at or before the age of 50.

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