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[Application of sandostatin in malignant bowel obstruction]
Jian Li1, Mao-lin Jing, Lin Shen
1Department of Digestive Disease, Peking University, School of Oncology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing 100036, China.
Objective:
To investigate the effects of sandostatin in the treatment of malignant bowel obstruction(MBO).
Methods:
The data of 51 patients with MBO from Aug. 1996 to June. 2004 were analyzed retrospectively. All the patients were divided into two groups: routine treatment group (n=19) and sandostatin combined with routine treatment group (n=32). Symptoms, gastrointestinal secretions, nasogastric tube(NGT) removing and effects of sandostatin on different obstructive location were observed.
Results:
The symptom improvement in sandostatin group was 20/32 (63.1%) which was significantly higher than 4/19 (21.1%) in routine treatment group (P< 0.01). The average G-I secretion was (398 +/- 152) ml and (834 +/- 306) ml in sandostatin and traditional group respectively and the difference was significant (P< 0.05). No severe side and toxic effects were found during therapy.
Conclusion:
Sandostatin can effectively relieve clinical symptoms and improve life quality in the bowel obstruction cases with advanced cancers.
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