Related Experiment Video
Updated: Jul 11, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Fractionated (split dose) radiosurgery in patients with recurrent brain metastases: implications for survival
P Davey1, M L Schwartz, D Scora
1Division of Radiation Oncology, Toronto Sunnybrook Regional Cancer Centre, Toronto, ON, Canada. phil.davey@sunnybrook.ca
British Journal of Neurosurgery
|September 14, 2007
Summary
Fractionated radiosurgery for brain metastases significantly improves patient survival compared to single-dose treatments. This approach warrants further investigation for better tumor control in neuro-oncology.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Oncology
Background:
- Conventional radiosurgery for brain metastases uses a single radiation dose.
- Fractionation of radiation doses has been proposed to enhance tumor control.
Purpose of the Study:
- To investigate the association between fractionated radiosurgery and patient survival.
- To identify prognostic factors influencing survival in patients with brain metastases.
Main Methods:
- Multivariate analysis of two prospective radiosurgery protocols (fractionated vs. single dose).
- Surgically applied stereotactic head frame used for precision.
- Radiosurgery planning based on contrast-enhanced CT scans.
- Comparison of outcomes between 69 two-fraction patients and 35 single-treatment patients.
Main Results:
- Fractionation was an independent determinant of survival.
- Two-fraction regimen patients survived a median of 30 weeks, compared to 16 weeks for single-fraction patients.
- Extracranial malignancy, performance status, multiple metastases, gender, and time to radiosurgery were also independent survival determinants.
Conclusions:
- Fractionated radiosurgery is associated with improved survival in brain metastases.
- Fractionated radiosurgery demonstrates potential for enhanced tumor control and warrants further clinical investigation.
