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Urticaria and angioedema in renal cell cancer patients treated with IL-2

Theodore F Logan1, Giovanni Strippoli, Macy I Levine

  • 1Indiana University School of Medicine, Division of Hematology/Oncology, Indianapolis, Indiana 46202, USA. tlogan@iupui.edu

Cancer Investigation
|September 14, 2007
PubMed

Interleukin-2 therapy has produced significant improvement in a proportion of patients with renal cell cancer. Dermatologic side effects, such as erythema, have been very common. However, we could find only 2 reports of urticaria in the medical literature. Here, we report 8 patients with renal cell cancer who developed urticaria in association with interleukin-2 therapy. The hives tended to occur at the end of a treatment cycle. Skin tests with IL-2 were negative in two patients. Urticaria did not worsen or consistently occur with repeated courses of interleukin-2 and anaphylaxis was not observed in any patient. Six of the 8 patients previously had urticaria unrelated to IL-2 therapy.

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