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Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and
Mieko Inagaki1, Shigeki Yoshida, Stephen Kennedy
1Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Objective:
We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population.
Methods:
We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls.
Results:
No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results.
Conclusion:
The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.
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