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Updated: Jul 11, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Irrigation with isoproterenol during ureterorenoscopy causes no systemic side-effects
Helene U Jung1, Joern S Jakobsen, Poul C Frimodt-Moeller
1Department of Urology, Fredericia Hospitals, Fredericia, Denmark. helene.jung@ki.au.dk
Scandinavian Journal of Urology and Nephrology
|September 14, 2007
Summary
Endoluminal isoproterenol irrigation during ureterorenoscopy did not cause cardiovascular side-effects in patients. This method may effectively reduce high renal pelvic pressure, a common complication of the procedure.
Area of Science:
- Urology
- Pharmacology
Background:
- Ureterorenoscopy (URS) irrigation can lead to elevated intrarenal pressures, potentially causing complications.
- Previous studies in pigs suggested endoluminal isoproterenol could reduce pelvic pressure.
Purpose of the Study:
- To evaluate the safety and efficacy of endoluminal isoproterenol irrigation during URS in humans.
- To assess potential systemic cardiovascular side-effects of this irrigation method.
Main Methods:
- Seven patients with renal stones undergoing URS were enrolled.
- A catheter measured renal pelvic pressure; blood pressure and heart rate were monitored.
- Isoproterenol (0.1 microg/ml) irrigation was compared to saline irrigation.
Main Results:
- Endoluminal isoproterenol irrigation showed no significant changes in mean heart rate or mean arterial pressure.
- Renal pelvic pressure was significantly lower with isoproterenol irrigation (19 mmHg) compared to saline (35 mmHg).
- High pelvic pressures (>300 mmHg) were observed during contrast medium injection.
Conclusions:
- Endoluminal isoproterenol irrigation during URS is safe, with no observed cardiovascular side-effects.
- Isoproterenol irrigation effectively reduces renal pelvic pressure during URS.
- This technique may offer a method to mitigate pressure-related complications in URS.
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