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Complement C4B protein in schizophrenia.

Karine R Mayilyan1, Alister W Dodds, Anna S Boyajyan

  • 1MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK. karine.mayilyan@bioch.ox.ac.uk

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
|September 14, 2007
PubMed
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Complement protein C4 deficiency is linked to autoimmune and infectious diseases. This study found lower C4B protein levels in Armenian schizophrenia patients, suggesting a role for complement C4 in mental health.

Area of Science:

  • Immunogenetics
  • Neuropsychiatry
  • Complement System Biology

Background:

  • Complement protein C4 (C4) deficiency is associated with autoimmune and infectious diseases.
  • Schizophrenia may involve infectious or autoimmune processes.
  • Previous research indicates complement C4B isotype abnormalities in schizophrenia.

Purpose of the Study:

  • To investigate complement C4A and C4B isotypes and serum C4B protein levels in Armenian schizophrenia patients.
  • To explore the association between C4 isotypes, C4B protein concentration, and schizophrenia.

Main Methods:

  • Genotyping for C4A and C4B isotypes.
  • Quantification of serum C4B protein concentration.
  • Comparison between schizophrenic patients and healthy controls.

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Main Results:

  • No significant difference in the frequency of C4BQ0 (a null allele) was observed between groups.
  • Schizophrenia patients exhibited significantly decreased serum C4B protein levels compared to healthy controls.

Conclusions:

  • Serum C4B protein concentration is significantly reduced in Armenian schizophrenia patients.
  • These findings suggest a potential role for the complement system, specifically C4B protein levels, in the pathophysiology of schizophrenia.