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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Eremophilane-type sesquiterpenes from Senecio nemorensis
Dong-Qing Fei1, Zhan-Xin Zhang, Jian-Jun Chen
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Three new eremophilane sesquiterpenes were isolated from Senecio nemorensis. These compounds, along with known ones, were tested for antimicrobial activity against Staphylococcus aureus and Candida albicans.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Pharmacognosy
Background:
- Senecio nemorensis L. (Compositae) is a plant source of diverse chemical compounds.
- Eremophilane-type sesquiterpenes are a class of natural products with potential biological activities.
Purpose of the Study:
- To isolate and characterize new compounds from Senecio nemorensis.
- To evaluate the antimicrobial potential of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via spectroscopic methods (IR, HR-ESI-MS, 1D and 2D NMR).
- Confirmation of structures through single-crystal X-ray diffraction.
Main Results:
- Three novel highly oxygenated eremophilane-type sesquiterpenes (1-3) were identified.
- Nine known compounds (4-12) were also isolated.
- Compounds 1-3 and 8-12 exhibited antimicrobial activity against Staphylococcus aureus and Candida albicans.
Conclusions:
- The study successfully identified new eremophilane sesquiterpenes from Senecio nemorensis.
- The isolated compounds show promise as antimicrobial agents.
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