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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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IL-33 is a chemoattractant for human Th2 cells.

Mousa Komai-Koma1, Damo Xu, Yubin Li

  • 1Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.

European Journal of Immunology
|September 14, 2007
PubMed
Summary

Interleukin-33 (IL-33) selectively attracts T helper 2 (Th2) cells, a key immune response. This cytokine promotes Th2 cell migration and accumulation, influencing mucosal immunity and inflammation.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Interleukin-33 (IL-33) is an IL-1 family cytokine that signals through the ST2 receptor.
  • ST2 is primarily expressed on T helper 2 (Th2) cells, not T helper 1 (Th1) cells.
  • IL-33 influences Th2-associated cytokine production (IL-5, IL-13) and contributes to mucosal organ defense and pathology.

Purpose of the Study:

  • To investigate the role of IL-33 in T helper cell migration.
  • To determine if IL-33 acts as a chemoattractant for Th2 cells.
  • To assess the impact of IL-33 on Th2 cell locomotion and accumulation in vivo.

Main Methods:

  • In vitro assessment of human Th2 and Th1 cell morphology and migration in response to recombinant IL-33.
  • Collagen gel invasion assay to quantify Th2 cell movement stimulated by IL-33.
  • In vivo footpad injection model in ST2-deficient mice adoptively transferred with Th2 cells to observe IL-33-mediated cell accumulation.

Main Results:

  • Recombinant IL-33 induced polarized morphology in human Th2 cells but not Th1 cells in vitro.
  • IL-33 significantly enhanced Th2 cell invasion into collagen gels in a dose-dependent manner.
  • Local administration of IL-33 in vivo led to the accumulation of adoptively transferred Th2 cells in ST2(-/-) mice.

Conclusions:

  • IL-33 functions as a selective chemoattractant for Th2 cells.
  • This chemoattractant property of IL-33 is linked to its pro-inflammatory roles.
  • IL-33 plays a critical role in orchestrating Th2 cell-mediated immune responses and associated pathologies.