"Recumbent" gait: relationship to the phenotype of "astasia-abasia"?
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Updated: Jul 11, 2026

05:53
Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease
Published on: July 18, 2019
Hieronymus D Boogaarts1, Wilson F Abdo, Bastiaan R Bloem
1Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Movement Disorders : Official Journal of the Movement Disorder Society
|September 14, 2007
Abstract:
Psychogenic gait disorders can present in many different ways. Among patients with a pure psychogenic gait disorder, buckling of the knee is the most common feature, followed by astasia-abasia. Here, we describe one such patient with a very unusual gait disturbance that might be regarded as a variant of astasia-abasia. The patient characteristics are described and discussed in a historical context.
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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

