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The genotoxicity study of garlic and pasipy herbal drops by peripheral blood micronucleus test

H Kalantari1, A Larki, S M Latifi

  • 1School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran. Hkalantari@ajums.ac.ir

Acta Physiologica Hungarica
|September 15, 2007
PubMed

Insights

This study assessed the genotoxic effects of garlic and pasipy herbal drops in mice using the micronucleus test. Results showed a significant, dose-dependent genotoxic effect compared to the negative control, warranting further investigation.

Area of Science:

  • Toxicology
  • Pharmacology
  • Genetics

Background:

  • The in vivo rodent micronucleus test is a standard assay for detecting chemical clastogenicity.
  • Herbal remedies like garlic and pasipy are widely used, necessitating safety evaluations.

Purpose of the Study:

  • To evaluate the genotoxic potential of garlic and pasipy herbal drops.
  • To determine the dose-dependent effects of these herbal preparations.

Main Methods:

  • The micronucleus test was employed in mice to assess genotoxicity.
  • Maximum Tolerated Dose (MTD) was established to define treatment dosages (MTD, 1/2 MTD, 1/4 MTD).
  • Mitomycin C served as the positive control, and pre-treatment blood samples as the negative control.

Main Results:

  • Both garlic and pasipy herbal drops demonstrated a significant, dose-dependent genotoxic effect compared to the negative control group (p < 0.05).
  • However, the genotoxic effects were not statistically significant when compared to a historical negative control group (p > 0.05).

Conclusions:

  • The findings indicate a significant genotoxic potential of garlic and pasipy herbal drops in mice under the tested conditions.
  • The observed genotoxicity, though significant compared to the immediate negative control, requires careful consideration and further research.

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