Related Experiment Video

Updated: Jul 11, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

Eva Schlosser1, Carolina Otero, Christine Wuensch

  • 1Division of Immunology, Department of Biology, Postbox M661, Universitatstrasse 10, University of Constance, Konstanz D-78457, Germany.

EMBO Reports
|September 15, 2007
PubMed
Summary

Signal peptidase cleavage prevents T-cell recognition of prostate stem cell antigen epitopes. This study reveals a novel pathway for generating major histocompatibility complex class I epitopes from ER-targeted proteins that fail to reach the ER.

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