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Improved biomimetic total synthesis of D,L-stephacidin A
Thomas J Greshock1, Robert M Williams
1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, USA.
Organic Letters
|September 15, 2007
Abstract:
The direct conversion of beta-hydroxyproline derivatives into 5-hydroxypyrazin-2(1H)-ones under Mitsunobu conditions has been discovered to be a general biomimetic protocol generating IMDA intermediates and has been applied to the concise, biomimetic total syntheses of D,L-stephacidin A and D,L-brevianamide B.

