Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperprolactinemia and autoimmune diseases.

Hedi Orbach1, Yehuda Shoenfeld

  • 1Department of Medicine B, Wolfson Medical Center, Holon, Israel.

Autoimmunity Reviews
|September 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[MICROSCOPIC POLYANGIITIS WITH VARIABLE PRESENTATION].

Harefuah·2020
Same author

The Powers of Flowers: Evaluating the Impact of Floral Therapy on Pain and Psychiatric Symptoms in Fibromyalgia.

The Israel Medical Association journal : IMAJ·2019
Same author

Survival of patient with giant cell arteritis: Impact of vision loss and treatment with aspirin.

Autoimmunity reviews·2019
Same author

Idiopathic Pulmonary Fibrosis.

The New England journal of medicine·2018
Same author

Prolactin: Another Important Player in the Mosaic of Autoimmunity.

The Israel Medical Association journal : IMAJ·2017
Same author

Intravenous immune globulins (IVIg) treatment for organizing pneumonia in a selective IgG immune deficiency state.

Immunologic research·2014
Same journal

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.

Autoimmunity reviews·2026
Same journal

Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment.

Autoimmunity reviews·2026
Same journal

Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.

Autoimmunity reviews·2026
Same journal

The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis.

Autoimmunity reviews·2026
Same journal

The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in thyroid diseases.

Autoimmunity reviews·2026
Same journal

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026
See all related articles

Prolactin (PRL) significantly influences autoimmune diseases, which are more prevalent in women. This hormone promotes autoimmunity by affecting B lymphocyte selection and survival, contributing to conditions like lupus and rheumatoid arthritis.

Area of Science:

  • Immunology
  • Endocrinology
  • Genetics

Background:

  • Autoimmune diseases exhibit a notable gender bias, predominantly affecting females.
  • Sex hormones, particularly estrogen and prolactin (PRL), play a crucial role in modulating immune responses and contributing to this bias.
  • Prolactin, secreted by the pituitary gland and lymphocytes, possesses immunostimulatory properties that can promote autoimmunity.

Purpose of the Study:

  • To investigate the role of prolactin (PRL) in the pathogenesis of autoimmune diseases.
  • To explore the mechanisms by which PRL influences immune cells and contributes to autoantibody production.
  • To examine the association between hyperprolactinemia (HPRL) and various organ-specific and multi-organ autoimmune conditions.

Main Methods:

  • Review of existing literature on PRL, sex hormones, and autoimmune diseases.

Related Experiment Videos

  • Analysis of studies investigating PRL's effects on B lymphocyte maturation, apoptosis, and proliferation.
  • Examination of clinical data correlating hyperprolactinemia with autoimmune disease activity.

    • Main Results:

    • PRL impairs negative selection of autoreactive B lymphocytes, enhances proliferative responses, and increases autoantibody production.
    • Hyperprolactinemia (HPRL) is frequently observed in autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), Hashimoto's thyroiditis (HT), and multiple sclerosis (MS).
    • No consistent correlation was found between PRL levels and the activity of these autoimmune diseases.

    Conclusions:

    • Prolactin (PRL) is implicated in promoting autoimmunity through various mechanisms affecting immune cell function.
    • Hyperprolactinemia (HPRL) is a common finding in numerous autoimmune diseases, suggesting its potential role in their development or progression.
    • While dopamine agonists show promise in preliminary studies for SLE, further research into genetic factors and PRL isoforms is warranted to fully understand and potentially target PRL's role in autoimmunity.