Related Experiment Video
Updated: Jul 11, 2026
06:39
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Coronary involvement in Takayasu's arteritis
Moshe Rav-Acha1, Leeor Plot, Nathan Peled
1Division of Internal Medicine, Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
Autoimmunity Reviews
|September 15, 2007
Summary
Takayasu's arteritis frequently affects coronary arteries, causing occlusions and worsening atherosclerosis. Managing inflammation is crucial for successful revascularization procedures in these patients.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Vascular Biology
Background:
- Takayasu's arteritis is a large vessel vasculitis affecting the aorta and its branches.
- Coronary artery involvement is a significant complication, impacting patient prognosis.
- Understanding the pathophysiology is key to improving treatment strategies.
Observation:
- Up to one-third of Takayasu's arteritis patients exhibit coronary artery abnormalities.
- Common findings include ostial stenosis and proximal coronary artery occlusion.
- Accelerated atherosclerosis exacerbates the vasculitic damage.
Findings:
- The vasculitic process in Takayasu's arteritis directly impacts coronary arteries.
- Enhanced atherosclerosis significantly contributes to disease progression and complications.
- Revascularization outcomes are often poor if the underlying inflammation is uncontrolled.
Implications:
- Effective control of systemic inflammation is paramount for successful coronary interventions.
- Development of novel grafting techniques using disease-unaffected vessels is ongoing.
- This highlights the need for integrated cardiovascular and rheumatological management.
Related Concept Videos
01:30Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...