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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Preliminary evidences of a NOS2A protective effect from relapsing-remitting multiple sclerosis
Ida Manna1, Maria Liguori, Paola Valentino
1Institute of Neurological Sciences, National Research Council, Contrada Burga 87050 Pianolago di Mangone (CS), Italy. i.manna@isn.cnr.it
Journal of the Neurological Sciences
|September 15, 2007
Summary
The inducible nitric oxide synthase gene (NOS2A) promoter region microsatellite (CCTTT)(14) allele appears to offer protection against Multiple Sclerosis (MS). This finding suggests a potential genetic marker for MS susceptibility.
Area of Science:
- Genetics
- Immunology
- Neurology
Background:
- The inducible form of Nitric Oxide Synthase (NOS2A) gene is investigated for its role in genetic predisposition to Multiple Sclerosis (MS).
- Microsatellite repeats in gene promoter regions are potential markers for disease susceptibility.
Purpose of the Study:
- To investigate the association between two NOS2A promoter microsatellites, (CCTTT)(n) and (AAAT)(n), and susceptibility to Multiple Sclerosis (MS).
Main Methods:
- Genotyping of (CCTTT)(n) and (AAAT)(n) microsatellites in the NOS2A promoter region.
- Analysis of allele frequencies in 113 Italian RRMS patients and 237 healthy controls.
Main Results:
- The (CCTTT)(14) allele was significantly less frequent in RRMS patients (11.5%) compared to healthy controls (25.3%) (p=0.003).
- The (CCTTT)(14) allele demonstrated a protective effect against MS (OR=0.348).
- No significant association was found for the (AAAT)(n) microsatellite with MS susceptibility.
Conclusions:
- The NOS2A (CCTTT)(14) allele may confer a protective effect against MS in the studied Italian population.
- This microsatellite marker warrants further investigation for its role in MS pathogenesis.
